Risk prediction models for familial breast cancer - PubMed
4 hours ago
- #breast cancer risk
- #familial risk prediction
- #meta-analysis
- The review identifies and assesses breast cancer risk prediction models for women with a family history.
- Meta-analysis includes four models: Gail/BCRAT, Tyrer-Cuzick/IBIS, BOADICEA, and BRCAPRO.
- Gail/BCRAT and BOADICEA are well-calibrated, Tyrer-Cuzick overpredicts risk, and BRCAPRO underpredicts risk.
- Discrimination accuracy is modest across all models, with no clear superior performer.
- Most studies have high or unclear risk of bias, and reporting in prognostic model studies is suboptimal.