A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects - PubMed
5 hours ago
- #periosteum
- #bone regeneration
- #tissue engineering
- A BioLiving periosteum is engineered to mimic natural periosteum for bone regeneration.
- The periosteum consists of a middle mini-tissue, a fiber-guiding layer, and a recruitment layer.
- The liquid substrate culture (LSC) method enhances endothelial cells' glycolytic activity, promoting a type-H phenotype.
- Type-H endothelial cells secrete growth factors to recruit endogenous cells.
- A radial topological structure guides recruited cells toward the central area of the defect.
- The combination of chemical and physical cues promotes centripetal bone regeneration.
- This approach is promising for treating severe bone defects.