The association between GLP-1 receptor agonists and fractures: a nationwide Danish nested case-control study - PubMed
7 hours ago
- #GLP-1 receptor agonists
- #bone health
- #fracture risk
- Study examines the association between GLP-1 receptor agonists (GLP1-RA) and fracture risk.
- Nationwide Danish nested case-control study with 337,648 fracture cases and 675,296 controls.
- Adjusted analysis shows GLP1-RA use was less frequent in fracture cases, suggesting a potential protective effect.
- Unadjusted analyses found no difference in GLP1-RA use between fracture cases and controls.
- GLP1-RA may reduce fracture risk, particularly major osteoporotic fractures (MOF).
- Background notes GLP1-RA's use in type 2 diabetes and weight loss, with concerns about bone loss from rapid weight loss.
- Methods involved matching fracture cases with controls by sex and birth year, using logistic regression for odds ratios.
- Results indicate adjusted ORs for any fracture (0.94) and MOF (0.88) were lower in GLP1-RA users.
- Conclusion suggests GLP1-RA could have a protective effect on bone health.
- Conflicts of interest noted among authors, with ties to pharmaceutical companies.