In vivo gene therapy with CAR-T cells - PubMed
4 hours ago
- #in vivo gene therapy
- #CAR-T therapy
- #hematologic malignancies
- In vivo CAR-T therapy involves generating CAR-T cells inside the body rather than ex vivo manufacturing.
- Proof-of-concept clinical studies show feasibility and therapeutic potential for this approach.
- Ex vivo CAR-T cells are effective for lymphoid hematologic malignancies but face logistic complexities that limit accessibility.
- In vivo methods present unique technical, biological, and safety challenges to address.