Endothelial C-type natriuretic peptide/guanylyl cyclase-B signaling prevents pulmonary arterial hypertension - PubMed
5 hours ago
- #C-type Natriuretic Peptide
- #Pulmonary Arterial Hypertension
- #Endothelial Signaling
- C-type natriuretic peptide (CNP) is released from endothelial cells and regulates blood pressure and vascular remodeling.
- Reduced CNP/GC-B signaling is observed in pulmonary arterial hypertension (PAH) models and patients.
- Endothelial-specific knockout of CNP or GC-B worsens PAH, while smooth muscle-specific knockout does not.
- CNP suppresses hypoxia-induced inflammatory and fibrotic gene expression in endothelial cells.
- CNP administration prevents PAH in mice and has therapeutic potential, especially in combination with existing treatments.
- The study suggests CNP/GC-B signaling as a key protective mechanism against PAH development.