Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer - PubMed
5 hours ago
- #BRCA1-deficient
- #EMT
- #Minimal Residual Disease
- Study focuses on spatiotemporal organisation of minimal residual disease (MRD) in BRCA1-deficient mammary tumours.
- Integrates single-cell RNA sequencing, spatial transcriptomics, and imaging mass cytometry across treatment timepoints.
- Identifies a chemotherapy-tolerant EMT cancer cell population in human BRCA1-deficient tumours, linked to adverse clinical outcomes.
- Reveals spatial distribution of residual EMT-like tumour cells within discrete anatomical niches.
- Suggests potential therapeutic vulnerabilities for targeting MRD persistence.