Bidirectional Crosstalk Between Intestinal Epithelium and Immune Microenvironment in Inflammatory Bowel Disease: Mechanisms and Therapeutic Implications - PubMed
6 hours ago
- #immune-epithelial crosstalk
- #IBD
- #therapeutic strategies
- Inflammatory bowel disease (IBD) involves chronic inflammation due to dysregulated interactions between intestinal epithelial cells (IECs) and immune components.
- The review explores the interplay between epithelial barrier integrity and immune-microenvironmental regulation in IBD.
- Key immune players include innate (neutrophils, macrophages, dendritic cells) and adaptive (Th1, Th17, Treg cells) immunity.
- Mechanisms discussed include NET-mediated epithelial damage, macrophage polarization via ROS/NOX4, and IL-22/STAT3-driven regeneration.
- Wnt/β-catenin and bile acid-TGR5 pathways are highlighted in intestinal stem cell renewal.
- Emerging therapies like anti-IL-23/IL-17 biologics and MSC-derived exosomes are evaluated.
- Single-cell omics and organoid technology are noted as advancing precision medicine approaches.
- Future research should focus on spatial-temporal mapping and organoid-based translational validation.