Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities - PubMed
2 days ago
- #Histone Modifications
- #Cardiovascular Disease
- #Epigenetic Therapeutics
- Cardiovascular diseases are the leading cause of death globally, driven by maladaptive transcriptional programs.
- Histone modifications like methylation, acetylation, and metabolite-derived acylations regulate chromatin accessibility and transcription in cardiovascular cells.
- Key histone marks such as H3K27me3 and H3K9ac, along with emerging metabolic sensors like lactylation, influence oxidative stress, endothelial dysfunction, and fibrosis.
- Therapeutic strategies include broad-spectrum histone deacetylase inhibitors versus precision approaches like bromodomain inhibition and epigenome editing.
- Translational challenges involve drug delivery and off-target effects, with single-cell and spatial multiomics proposed for advancing precision epigenetic therapeutics.