The association between serum trace elements and iron deficiency anemia in children and adolescents: a systematic review and meta-analysis - PubMed
4 hours ago
- #pediatric health
- #iron deficiency anemia
- #trace elements
- Iron deficiency anemia (IDA) is the most prevalent anemia in children and adolescents globally, with potential involvement of trace elements beyond iron.
- A systematic review and meta-analysis of 8 articles with 12 datasets and 1105 participants analyzed serum levels of iron (Fe), zinc (Zn), copper (Cu), and magnesium (Mg) in pediatric IDA.
- IDA patients had significantly lower levels of Fe (-13.07 μmol/L), Zn (-4.33 μmol/L), and Mg (-18.17 μmol/L), but higher levels of Cu (4.33 μmol/L) compared to controls.
- High heterogeneity (I² > 95%) was observed for Fe, Zn, and Cu, but subgroup analyses showed consistent trends across age, gender, and geography.
- The findings suggest broad trace element alterations in IDA, highlighting their potential roles in anemia pathophysiology and informing comprehensive nutritional management strategies.