Structural insights into HRI kinase activity and inhibition - PubMed
a day ago
- #HRI kinase
- #structural biology
- #eIF2alpha
- HRI kinase phosphorylates eIF2α and is involved in sensing proteotoxic stresses.
- It is a potential therapeutic target in multiple myeloma and neurodegenerative diseases.
- Regulatory mechanisms of HRI are not fully understood despite years of research.
- HRI activity is modulated by interactions with proteins, cofactors, and haem.