GEF-H1 upon microtubule destabilization drives ZBP1-dependent necroptosis - PubMed
5 hours ago
- #microtubule
- #inflammation
- #necroptosis
- GEF-H1 released upon microtubule destabilization triggers necroptosis.
- GEF-H1 interacts with DHX9, both are essential for necroptosis.
- GEF-H1 translocates to the nucleus, recruits DHX9 and RNA Pol II to the ZBP1 promoter, increasing ZBP1 expression.
- GEF-H1 signaling also promotes LPS-induced cell death and inflammation.
- Study identifies a novel role for GEF-H1 in necroptosis and inflammation pathways.