Cytoskeletal remodeling promotes tunneling nanotube formation and drives cardiac resident cell mitochondrial transfer in sepsis - PubMed
14 hours ago
- #mitochondrial transfer
- #tunneling nanotubes
- #sepsis
- Sepsis-induced cardiac dysfunction involves complex intercellular communication beyond direct cardiomyocyte damage.
- Tunneling nanotubes (TNTs) facilitate intercellular mitochondrial transfer, playing a critical role in septic cardiac remodeling.
- Sepsis reprograms cardiac endothelial cells, fibroblasts, and macrophages, leading to dysfunctional mitochondrial respiration.
- Drp1-driven cytoskeletal remodeling orchestrates TNT biogenesis, enabling long-range organelle trafficking.
- Cardiac-specific Drp1 knockout disrupts TNT-mediated mitochondrial exchange, reversing metabolic deterioration and cellular reprogramming.
- Drp1-mediated TNT networks serve as nanoscale conduits for organelle communication, offering therapeutic potential for mitochondrial dysfunction in sepsis.