15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN - PubMed

4 days ago

The Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating autosomal dominant Alzheimer's disease (ADAD).
Established in 2008 with NIA support, DIAN Obs collects comprehensive data to understand brain aging and ADAD progression.
Participants, including mutation carriers and non-carriers from affected families, undergo clinical, cognitive, imaging, and biochemical assessments.
Data includes genetic, clinical, cognitive, imaging, and biochemical measures, enabling detailed examination from presymptomatic to symptomatic AD stages.
The study aims to advance understanding of AD pathophysiology, aging, and therapeutic interventions.
DIAN Obs serves as a globally accessible resource for researchers.
Key mutations involved are in APP, PSEN1, or PSEN2 genes, causing ADAD with high penetrance and predictable onset.
Biospecimens collected include cerebrospinal fluid, plasma, serum, and whole blood for multi-omic analyses.
The study has significant funding and collaborations, including pharmaceutical partners and research organizations.
Several authors have disclosed competing interests, including research funding, advisory roles, and consulting fees from biotech and pharmaceutical companies.

Hasty Briefsbeta