STING-STAT1-ZBP1 axis orchestrates PANoptotic signaling in ischemia-reperfusion induced acute kidney injury - PubMed
5 hours ago
- #PANoptosis
- #Acute Kidney Injury
- #Ischemia-Reperfusion Injury
- The STING-STAT1-ZBP1 axis regulates PANoptotic signaling in ischemia-reperfusion induced acute kidney injury (IRI-AKI).
- IRI-AKI involves mechanisms of ischemia and reperfusion injury, with PANoptosis identified as a key cell death pathway.
- Single-cell sequencing reveals cytopathological mechanisms in AKI, highlighting both homogeneity and heterogeneity across different etiologies.
- The article discusses small-molecule compounds targeting PANoptosis for therapeutic interventions in diseases like AKI.
- No competing interests declared by the authors.