Protocatechualdehyde-functionalized BMSC-derived exosomes orchestrate calcium signaling in the immunoinflammatory microenvironment to promote periodontal regeneration - PubMed
5 days ago
- #calcium signaling
- #BMSC-derived exosomes
- #periodontal regeneration
- Protocatechualdehyde-functionalized BMSC-derived exosomes (PA@BMSC Exo) enhance stability and calcium influx.
- PA@BMSC Exo promotes osteogenic differentiation, immunoinflammatory regulation, and angiogenesis in periodontal regeneration.
- The engineered exosomes improve periodontal tissue regeneration by modulating calcium signaling and the inflammatory microenvironment.
- Bioinformatic analysis links enhanced osteogenic differentiation to calcium influx via the voltage-gated calcium channel Cav3.3.
- PA@BMSC Exo shows potential for clinical treatment of chronic periodontitis.