Integrative multi-omics dissection identifies ACO2, KLF5, and IMP4 as central regulators of the mitochondrial-immune axis in ulcerative colitis - PubMed
4 hours ago
- #Multi-Omics Analysis
- #Ulcerative Colitis
- #Immunometabolism
- Identified ACO2, KLF5, and IMP4 as central regulators linking mitochondrial metabolism and immune response in ulcerative colitis through integrative multi-omics analysis.
- Used GWAS, eQTL, bulk transcriptomics, and single-cell RNA-seq data to validate these genes, showing downregulation in UC tissues and correlation with immune cell infiltration.
- Found ACO2 and KLF5 primarily expressed in macrophages and reduced in inflamed areas, while IMP4 showed cell-type-specific dynamics.
- In a DSS-induced mouse model, Aco2 and Klf5 decreased with disease severity, with metabolic pathways like oxidative phosphorylation and glycolysis implicated.
- Highlights these genes as potential biomarkers and therapeutic targets for UC, offering insights into immunometabolism mechanisms.