Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation - PubMed
3 days ago
- #acute pancreatitis
- #lipid metabolism
- #ion channels
- Oleic acid (OA) promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis (HTG-AP).
- OA disrupts endothelial barrier function via the PIEZO1/NR4A1/CPT1A axis, impairing fatty acid oxidation (FAO).
- Clinical and animal data show elevated plasma OA in HTG-AP, correlating with acute lung injury (ALI) severity.
- PIEZO1 activation by OA suppresses NR4A1, leading to CPT1A downregulation and FAO impairment.
- Endothelial-specific Piezo1 knockdown alleviates HTG-AP-associated ALI in mice, suggesting therapeutic potential.