Pyrophosphate Scintigraphy Changes After Tafamidis Therapy - Proposed Novel Index From Quantitative Single-Photon Emission Computed Tomography - PubMed
7 days ago
- #Tafamidis
- #ATTR-CM
- #Pyrophosphate scintigraphy
- Bone scintigraphy is crucial for diagnosing transthyretin cardiac amyloidosis (ATTR-CM) due to available disease-modifying therapy.
- A retrospective study of 24 ATTR-CM patients analyzed amyloid accumulation volume (AAV) in the left ventricular wall using quantitative single-photon emission computed tomography.
- AAV significantly decreased after tafamidis treatment (591.1±426.0 vs. 213.8±201.9, P<0.0001).
- AAV correlated with troponin T levels (R=0.49, P=0.022).
- AAV provides a precise quantitative evaluation of amyloid burden in ATTR-CM.