E-cadherin inactivation shapes tumor microenvironment specificities in invasive lobular breast cancer - PubMed
3 hours ago
- #tumor microenvironment
- #invasive lobular breast cancer
- #E-cadherin
- E-cadherin (CDH1) loss in invasive lobular breast carcinoma (ILC) prevents differentiation of FAP+ inflammatory cancer-associated fibroblasts (iCAF) into myofibroblastic CAF, leading to iCAF accumulation.
- Accumulated FAP+ iCAF attract tumor-infiltrating lymphocytes (TILs) into the tumor center, shaping their spatial organization.
- CDH1-inactivated ILC cancer cells promote immune escape by lacking retention and activation of ITGAE-expressing resident memory CD8+ T lymphocytes (TRM).
- Reciprocal interactions between CDH1-inactivated cancer cells, FAP+ iCAF, and CD8+ TRM explain why high TIL content is associated with poor prognosis in ILC patients.
- This mechanism is generalizable to other CDH1-inactivated cancer types.