Exercise for Non-Motor Symptoms of Parkinson's Disease: An Evidence-Based Review of Clinical Trials, Dosing Considerations, and Mechanistic Insights - PubMed
6 hours ago
- #Parkinson's disease
- #exercise intervention
- #non-motor symptoms
- Exercise therapy is recognized as a complementary treatment for Parkinson's disease (PD), with growing attention on its benefits for non-motor symptoms (NMS) that impact quality of life.
- Evidence suggests exercise improves multiple NMS domains in PD, such as mood symptoms (anxiety and depression), cognitive dysfunction, sleep disturbances, pain, and autonomic dysfunction.
- Current evidence is limited by small sample sizes, heterogeneous interventions, and inconsistent outcome measures, highlighting the need for further research on different exercise modalities.
- The review discusses how exercise parameters like intensity and duration regulate NMS, exploring potential mechanisms including neuroimmune modulation and neuroplasticity for clinical applications.