UVB Upregulates Inflammatory Cytokines in Rosacea Cell Model by Promoting the Expression of TRPVs and TLR2 - PubMed
2 months ago
- #UVB
- #rosacea
- #inflammation
- UVB radiation increases inflammatory cytokines in rosacea by upregulating TRPV1, TRPV4, and TLR2 expression.
- TRPV1 and TLR2 antagonists reduce IL-1β and IL-8, while TRPV4 antagonists reduce IL-6 in rosacea models.
- UVB exposure alters histone modification (H3K4me3) in the TRPV1 promoter region, suggesting epigenetic regulation.
- The study links UVB-induced inflammation in rosacea to TRPVs and TLR2, highlighting potential therapeutic targets.