Metabotropic glutamate receptor 5 is associated with plasma GFAP dependent on age - PubMed
2 hours ago
- #Cognitive Impairment
- #GFAP
- #mGluR5
- The study explored the link between mGluR5 receptor availability and plasma biomarkers in 71 individuals with cognitive impairment, including CU, EOCI, and LOCI groups.
- Using 18F-Florbetapir and 18F-PSS232 imaging, mGluR5 availability was found positively associated with plasma GFAP levels in individuals over 65 and the LOCI group.
- This positive association between mGluR5 and GFAP in the LOCI group was significant only in the Aβ-positive subgroup, indicating age-dependent relationships.
- Findings suggest increased mGluR5 availability correlates with higher plasma GFAP, highlighting potential roles in aging and cognitive impairment mechanisms.
- The research involved statistical analyses like partial correlation, mediation, and interaction to assess biomarker relationships, supported by various funding sources.