The deficiency of circSLC8A1 fosters tubular partial EMT-induced renal fibrosis through upregulating Annexin A2 signaling - PubMed
7 hours ago
- #renal fibrosis
- #Annexin A2
- #circSLC8A1
- circSLC8A1 deficiency drives renal fibrosis by promoting partial EMT in tubular epithelial cells.
- Overexpression of circSLC8A1 reduces fibrosis in vivo, while its loss worsens pEMT in TECs.
- circSLC8A1 binds to Annexin A2 (ANXA2) and promotes its degradation via the ubiquitin-proteasome pathway.
- Downregulation of circSLC8A1 stabilizes ANXA2 protein, accelerating pEMT and fibrosis.
- The circSLC8A1-ANXA2 axis is a novel therapeutic target for treating chronic kidney disease and renal fibrosis.