Impact of vitamin D supplementation on all-cause mortality: Randomized trials revisited - PubMed
a day ago
- #Vitamin D
- #Randomized Trials
- #Mortality
- Vitamin D insufficiency and deficiency are linked to higher all-cause mortality.
- Large trials (VITAL and D-Health) in vitamin D-sufficient populations showed no mortality benefits from supplementation.
- Emulated trials using UK Biobank data estimated effects of vitamin D supplementation in insufficient/deficient populations.
- Null results were found in emulated trials matching original trial 25(OH)D distributions.
- Significant mortality reduction was expected in populations with vitamin D insufficiency (HR 0.85, 0.81) or deficiency (HR 0.79, 0.75).
- Vitamin D supplementation may have major mortality benefits in insufficient/deficient populations, but not in sufficient ones.