Adhesive Microneedle-Nanosheets With Temporally Orchestrated Antimicrobial, Immunomodulatory, and Osteogenic Functions for Periodontal Regeneration - PubMed
5 hours ago
- #Periodontal Regeneration
- #GBR Membrane
- #Temporal Drug Delivery
- Development of a microneedle-nanosheet composite membrane for guided bone regeneration (GBR) in periodontal defects.
- Features adaptive adhesion to bone surfaces via nanoscale properties and sequential targeting of bacterial and inflammatory phases in periodontitis.
- Sustained release of antimicrobial peptides from GelMA layer to control pathogens, and slow delivery of mesenchymal stem cell-derived exosomes from microneedles.
- Exhibits mechanical stability, antibacterial activity, biocompatibility, and promotes osteogenesis and angiogenesis in vitro.
- Demonstrates enhanced immunomodulation, osteogenesis, angiogenesis, and alveolar bone regeneration in animal models.
- Reduces periodontal-associated bacterial communities and activates immune signaling pathways.