Aerobic Exercise Mitigates Perimenopausal Dysfunction and Is Associated With Gut Microbiota Remodeling and Multi-Organ Crosstalk - PubMed
6 hours ago
- #perimenopause
- #gut microbiota
- #aerobic exercise
- Aerobic exercise (AE) mitigates perimenopausal dysfunction by restoring systemic homeostasis and remodeling gut microbiota.
- AE improves metabolic-immune balance by normalizing estradiol levels, reducing pro-inflammatory cytokines, and elevating IL-10 expression.
- Behavioral and neurochemical analyses show reduced cortisol and restored monoamine turnover, alleviating anxiety-like behavior.
- AE enhances skeletal and reproductive function through improved scale mineralization, reduced oocyte apoptosis, and altered enzyme activity.
- 16S rRNA sequencing reveals AE enriches Bacillota and Cetobacterium while depleting Pseudomonadota and Legionella in gut microbiota.
- Correlation analyses link microbial shifts with systemic restoration, highlighting a gut-brain-bone-ovary network.
- AE serves as a system-level intervention for perimenopausal dysfunction, offering a framework for future combinatorial strategies.