Associations of TyG-Derived Indices with Cardiometabolic Multimorbidity Risk in Community-Dwelling Older Adults: A Longitudinal Analysis Based on the GOLD-Health Cohort - PubMed
5 hours ago
- #cardiometabolic multimorbidity
- #older adults
- #insulin resistance
- TyG-derived adiposity indices, particularly TyG-WHtR and TyG-BMI, are strong independent risk markers for incident cardiometabolic multimorbidity (CMM) in older adults.
- The atherogenic index of plasma (AIP) mediates 7.5-33.0% of the association between TyG-derived indices and CMM risk, suggesting atherogenic dyslipidemia is a key pathway.
- Study based on a longitudinal cohort of 304,586 community-dwelling adults aged ≥65, with 7,816 developing CMM over a median 4.3-year follow-up.
- TyG-WHtR showed the strongest association with CMM risk (HR=2.150 for highest vs. lowest quartile), closely followed by TyG-BMI (HR=2.146).
- Findings indicate these accessible metrics could be used for risk stratification and early intervention in primary care to target insulin resistance progression.