Ginkgetin alleviates sepsis-induced acute lung injury by promoting autophagy via inhibiting ubiquitination of Laptm5 in macrophages - PubMed
3 months ago
- #Sepsis
- #Autophagy
- #Inflammation
- Ginkgetin (GK) alleviates sepsis-induced acute lung injury (SI-ALI) by promoting autophagy in macrophages.
- GK inhibits ubiquitination of lysosomal-associated transmembrane protein 5 (Laptm5), enhancing autophagy-mediated degradation of TBK1 and reducing inflammation.
- Key ubiquitination sites of Laptm5 (K86 and K122) were identified, with GK targeting ubiquitin-protein ligase E3C (Ube3c) to inhibit this process.
- The study suggests GK as a potential therapeutic for SI-ALI by modulating macrophage autophagy and inflammatory responses.