Circulating proteomic landscape of lung function - PubMed
2 days ago
- #biomarkers
- #proteomics
- #lung function
- Large-scale proteomic study identifies 1055 circulating proteins significantly associated with lung function traits.
- Study involved 20,823 adults from diverse ancestries (71% European, 15% African, 15% Asian) across five cohorts.
- Used SOMAScan™ platform to assess 4693 proteins; spirometry parameters (FEV1, FVC, FEV1/FVC) were analyzed.
- Identified 473 enriched pathways, including inflammation and organismal injury, with key proteins like STAT3 and EGFR.
- Validated 411 protein associations in UK Biobank using Olink 3K platform (560 overlapping proteins).
- 179 proteins linked to COPD; Mendelian randomization suggests potential causality for 34 proteins.
- 89% of associated proteins are novel findings not previously linked to lung function.
- Findings could enhance understanding of lung disease pathogenesis, biomarker discovery, and therapeutic strategies.