Advances in the pathophysiology and treatment of diabetic peripheral neuropathy - PubMed
5 hours ago
- #diabetic peripheral neuropathy
- #DPN treatment
- #neuropathy pathophysiology
- Diabetic peripheral neuropathy (DPN) is a debilitating disorder causing sensory loss, gait dysfunction, skin ulceration leading to amputations, and neuropathic pain.
- DPN negatively impacts mood, quality of life, and is associated with increased mortality.
- Aggressive hyperglycemia treatment does not adequately prevent DPN, especially in type 2 diabetes, highlighting the need for new treatments.
- Recent advances include understanding risk factors, molecular mechanisms like axoglial interactions, and metabolic derangements beyond hyperglycemia.
- Challenges persist in translating preclinical insights into effective patient treatments.
- The review covers DPN epidemiology, risk factors (including social determinants), pathophysiology, genetics, diagnosis, treatment, outcomes assessments, and biomarkers.
- It emphasizes recent advances and future directions in DPN research.