Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer - PubMed
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- #FTO
- #breast-cancer
- Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer.
- Activation of mitochondrial respiration with uncouplers (NEN, BAM15) reduces MSCP activity and enzyme levels (SHMT2, MTHFD2, MTHFD1L).
- Post-transcriptional suppression of MSCP enzymes is mediated by increased NAD+:NADH ratio, leading to reduced 2-HG and FTO activation.
- FTO inhibition restores MSCP enzyme levels, confirming its regulatory role.
- Dietary mitochondrial uncoupling suppresses lung metastasis in vivo, suggesting therapeutic potential.