RIPK3 Orchestrates Scar-Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis - PubMed
3 days ago
- #immunometabolism
- #RIPK3
- #pulmonary fibrosis
- RIPK3 is significantly upregulated in IPF patients and mice, particularly in macrophages.
- Macrophage-specific RIPK3 knockout mice resist bleomycin-induced fibrosis.
- RIPK3 regulates scar-associated macrophages (SAMs), influencing pulmonary fibrosis progression.
- Signature markers of SAMs include Spp1, Arg1, and Cx3cr1.
- RIPK3 deficiency inhibits TGF-β-driven arginine conversion to polyamines via the AKT-mTOR pathway.
- Targeting RIPK3's immunometabolic functions may offer therapeutic strategies for IPF.