Metastatic Breast Cancer Outcome in a Real-World Setting: Analysis for Long-Term Survival and Curability in a Prospective Dataset - PubMed
7 days ago
- #Long-term Survival
- #Metastatic Breast Cancer
- #Real-world Data
- Metastatic breast cancer (MBC) is generally considered incurable, but treatment advances have improved overall survival (OS).
- Real-world data analysis of 920 MBC patients (1999-2021) identified factors linked to OS ≥ 10 years, including de novo MBC, single metastatic site, HER2-positive disease, and clinical trial participation.
- First-line chemotherapy and endocrine therapy showed similar or better time-to-next treatment (TTNT) and OS compared to clinical trial results.
- 16% of patients were long-term survivors (LTS) or long-term responders (LTR), with 8.7% potentially cured.
- The study suggests that effective clinical trial outcomes can be replicated in real-world settings, offering optimism for MBC patients.