α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis models - PubMed
6 hours ago
- #metabolism
- #epigenetics
- #osteoarthritis
- α-Ketoglutarate (αKG) protects cartilage from damage in osteoarthritis (OA) models.
- Impaired glutaminolysis in chondrocytes is linked to OA onset and progression.
- OA pathogenic factors increase H3K27me3 deposition on glutaminolysis gene promoters, impairing metabolism.
- αKG facilitates Kdm6b-dependent H3K27me3 demethylation, restoring glutaminolysis and metabolic homeostasis.
- Elevated Ube2o expression leads to TRAF6 ubiquitination, inhibiting NF-κB signaling and reversing OA pathology.
- αKG alleviates OA by reversing pathological reprogramming of glycolysis and oxidative phosphorylation.