Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and BAP1 loss - PubMed
a day ago
- #interferon response
- #BAP1
- #ccRCC
- Single-cell ATAC-seq profiling identified an interferon response program in ccRCC linked to poor prognosis and BAP1 loss.
- BAP1 mutation induces a tumor-intrinsic interferon response, potentially triggered by dysregulated endogenous retroviruses.
- The interferon response program is associated with features of inflammation and immune evasion in the tumor microenvironment.
- Findings suggest tumor-intrinsic interferon signaling as a driver of BAP1-associated aggressiveness in RCC.
- Immune evasion pathways highlighted as potential therapeutic targets.