Recent advances in LNP-mRNA vaccines - PubMed
8 hours ago
- #Immunotherapy
- #Nanomedicine
- #LNP-mRNA vaccines
- LNP-mRNA vaccines combine lipid nanoparticle (LNP) technology with mRNA engineering, using ionizable lipid, phospholipid, cholesterol, and PEGylated lipid for stability and delivery.
- Innovations in mRNA chemistry, like nucleoside modification and untranslated region optimization, enhance translation efficiency and control immune responses.
- LNP-mRNA platforms, proven in COVID-19 vaccines, show potent immune responses against viral, bacterial, and cancer targets in preclinical and clinical studies.
- Rational integration of biomaterial design and mRNA engineering defines next-generation programmable immunotherapies for preventive and therapeutic applications.