Progression from symptom onset to rheumatoid arthritis: is the trajectory similar in anticitrullinated protein antibody-positive and -negative disease? A comparative longitudinal study - PubMed
3 hours ago
- #ACPA antibodies
- #rheumatoid arthritis
- #disease progression
- ACPA-positive patients take longer from symptom onset to clinical presentation but progress faster to RA after presentation.
- ACPA-negative patients experience more morning stiffness at symptom onset, clinical presentation, and until RA development.
- ACPA-negative patients report more hand pain and tender hand joints throughout progression.
- ACPA-positive patients show a quicker increase in CRP levels and greater forefoot inflammation before RA development.
- Differences suggest distinct inflammatory mechanisms and may require tailored preventive strategies for each subtype.