Antifungal susceptibility and in vitro virulence characteristics of clinical Magnusiomyces/Saprochaete isolates: a multicenter study from Türkiye - PubMed
6 hours ago
- #Antifungal susceptibility
- #Virulence factors
- #Magnusiomyces
- Study investigates antifungal susceptibility and virulence traits of Magnusiomyces/Saprochaete isolates in Türkiye.
- 133 clinical isolates (2010-2024) from 18 hospitals were analyzed using MALDI-TOF MS and ITS/LSU sequencing.
- Species distribution: 80.4% Magnusiomyces capitatus, 19.6% Magnusiomyces clavatus.
- High agreement (99.2%) between MALDI-TOF MS and sequencing for species identification.
- Voriconazole, amphotericin B, and posaconazole showed the lowest MICs; fluconazole had limited activity.
- 97.7% of isolates were strong biofilm producers, with M. capitatus showing higher biofilm production.
- M. clavatus exhibited higher caseinase and esterase activity compared to M. capitatus.
- Study highlights the importance of accurate species-level identification for treatment strategies.
- Findings suggest prioritizing voriconazole and amphotericin B in species-guided treatments.