ATP13A2 restrains macrophage NLRP3 inflammasome activation to repress neurodegeneration via modulating mitochondrial homeostasis - PubMed
7 hours ago
- #Parkinson's disease
- #mitochondrial homeostasis
- #NLRP3 inflammasome
- ATP13A2 mutations in Parkinson's disease (PD) lead to loss-of-expression, affecting macrophage function.
- Myeloid ATP13A2 deficiency triggers NLRP3 inflammasome activation via lysosomal alkalization and mitochondrial disruption.
- PD-linked ATP13A2 mutants fail to suppress NLRP3 hyperactivation in human monocytes.
- Macrophages from a PD patient with ATP13A2 L927P mutation show excessive NLRP3 activation due to lysosomal-mitochondrial dysfunction.
- The study highlights the role of macrophage NLRP3 dysregulation in PD pathogenesis, especially in ATP13A2 mutation cases.