In situ architecture of developmentally programmed mitophagy reveals ER-phagophore membrane continuity - PubMed
5 hours ago
- #ER Membrane Continuity
- #Drosophila Development
- #Mitophagy
- This study explores mitophagy in the developing Drosophila intestine, using advanced imaging techniques like cryo-ET and cryo-FIB milling.
- It finds that the endoplasmic reticulum (ER) forms continuous membrane connections with the phagophore during mitophagosome formation.
- In Vps13D mutant enterocytes, stalled mitochondrial engulfment is linked to persistent ER-phagophore membrane continuities.
- These results support a model where direct ER-phagophore membrane continuity facilitates rapid mitophagosome formation.