Utility of risk assessment and identification of risk factors for drug-resistant pathogens in hospital-acquired and ventilator-associated pneumonia: systematic reviews and meta-analyses - PubMed
6 hours ago
- #drug-resistant pathogens
- #HAP/VAP
- #risk factors
- The study conducted two systematic reviews and meta-analyses to assess the utility of risk assessment for drug-resistant pathogens in hospital-acquired and ventilator-associated pneumonia (HAP/VAP).
- In the first review, high-risk HAP/VAP patients had significantly higher rates of drug-resistant pathogen detection and all-cause mortality compared to low-risk patients.
- The second review identified five key risk factors for drug-resistant pathogens in HAP/VAP: onset in the ICU, sepsis/septic shock, previous antibiotics treatment, bedridden state/poor functional status, and chronic kidney disease.
- These findings support using risk assessment for guiding initial antibiotic selection in HAP/VAP management.
- The study protocol was registered with a clinical trials registry, and no major competing interests were reported among most authors.