Ginsenoside Rg2 ameliorates acute cold exposure/rewarming-induced myocardial injury via modulating HMGB1/TLR4/NF-κB and PGC-1α signaling pathways: Role of SIRT1 - PubMed
5 hours ago
- #Myocardial injury
- #Ginsenoside Rg2
- #SIRT1
- Ginsenoside Rg2 (Rg2) protects against acute cold exposure/rewarming (ACE/R)-induced myocardial injury.
- Rg2 works by modulating the HMGB1/TLR4/NF-κB pathway to reduce inflammation and the PGC-1α pathway to improve mitochondrial function.
- The study used both in vivo (rat models) and in vitro (primary cardiomyocytes) approaches to confirm Rg2's cardioprotective effects.
- SIRT1 activation by Rg2 is crucial for its therapeutic benefits, as shown by genetic and pharmacological inhibition studies.
- Rg2 improves cardiac function, reduces inflammation, and mitigates mitochondrial damage in ACE/R-induced injury.
- The findings highlight Rg2's potential as a treatment for cold-induced cardiovascular complications.