Synergistic Effects of Compound Dendrobium Candidum and Antihypertensive Medications on Refractory Hypertension in Spontaneously Hypertensive Rats - PubMed
5 hours ago
- #angiotensin receptors
- #hypertension
- #synergistic effect
- Compound Dendrobium Candidum (CDC) combined with antihypertensive drugs enhances blood pressure control in hypertensive rats.
- CDC increases the rate of achieving blood pressure targets (<150 mmHg) from 0% to 100% in refractory hypertension cases.
- The study found CDC reduces compensatory increases in AT1R and AT2R levels caused by antihypertensive treatments.
- CDC with antihypertensive drugs lowers mRNA and protein expression of AT1R and AT2R in glomerular endothelial cells.
- The mechanism involves attenuation of excessive AT2R expression, offering a new approach for resistant hypertension treatment.