Microbiota and Alzheimer's disease: mechanistic insights from a multi-organ perspective - PubMed
3 months ago
- #Alzheimer's disease
- #Neuroinflammation
- #Microbiota
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder with multifactorial mechanisms.
- Dysbiosis (microbiota imbalance) may play a key role in AD pathogenesis across multiple organs like gut, oral cavity, nasal passages, lungs, and skin.
- Microbial imbalances can lead to neuroinflammation, immune dysfunction, and metabolic disturbances via host-microbiota networks.
- The review introduces the 'Multi-Axis Co-Regulation' concept and evaluates microbial biomarkers for early AD diagnosis.
- Microbiota-targeting interventions (probiotics, dietary modulation, fecal microbiota transplantation, oral microbiome-based therapies) show promise for AD prevention and treatment.