Cuproptosis in cancer: emerging mechanism and therapeutic opportunities - PubMed
7 hours ago
- #copper-based therapeutics
- #cuproptosis
- #cancer therapy
- Cuproptosis is a mitochondria- and copper-dependent regulated form of cell death.
- Mechanism involves aggregation of lipoylated proteins in the tricarboxylic acid cycle, triggering proteotoxic stress.
- Destabilization of iron-sulfur cluster proteins leads to mitochondrial dysfunction.
- Recent studies reveal multilayered regulation through core proteins, mitochondrial function, and copper homeostasis.
- Development of copper-based therapeutics, including ionophores and nanomaterials, is underway.
- Smart-responsive nanomaterials improve precision in tumor delivery and resistance circumvention.