Circulating levels of insulin-like growth factor I (IGF-I) and risk of multiple myeloma: An observational and Mendelian randomisation study - PubMed
5 hours ago
- #Mendelian randomization
- #multiple myeloma
- #IGF-I
- Study examines the association between circulating IGF-I levels and multiple myeloma (MM) risk using observational and Mendelian randomization (MR) approaches.
- Higher circulating IGF-I levels are associated with increased MM risk (HR per SD increase = 1.11, 95% CI: 1.01-1.22).
- Genetically inferred IGF-I levels also show an increased MM risk (OR = 1.27, 95% CI: 1.05-1.54).
- No association found between IGFBP-3 levels and MM or other lymphoid neoplasms (LNs).
- Secondary analysis suggests IGF-I levels may influence chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) risk in obese males.
- Findings support a potential role of IGF-I in MM susceptibility, warranting further investigation.