HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells - PubMed
4 hours ago
- #Radioresistance
- #GTP Synthesis
- #Glioblastoma
- HSPA6 promotes radioresistance in glioblastoma stem cells (GSCs) by increasing GTP synthesis.
- HSPA6 interacts with and activates IMPDH2 via ROCK2-mediated phosphorylation at S416, enhancing its enzyme activity.
- Targeting HSPA6 and IMPDH2 together with radiation improves survival in GBM mouse models.
- This pathway suggests a potential therapeutic strategy to overcome radiotherapy resistance in glioblastoma.