Clinical Impact of Initial Low Molecular Weight Heparin Use in Hospitalised Patients with Venous Thromboembolism Treated with Direct Oral Anticoagulants: A Propensity Score Matched Study - PubMed
6 hours ago
- #direct oral anticoagulants
- #low molecular weight heparin
- #venous thromboembolism
- The study evaluated adherence to LMWH initiation protocols before DOAC therapy in hospitalized VTE patients using Taiwan's data from 2012-2022.
- For dabigatran/edoxaban users, LMWH initiation did not significantly affect recurrent VTE, major bleeding, or all-cause mortality at 30 days.
- For apixaban/rivaroxaban users, LMWH initiation was linked to a higher risk of recurrent VTE but not major bleeding or mortality.
- No significant difference in LMWH's effects was found between the two pharmacological groups.
- The findings suggest varying impacts based on DOAC type, with a need for further validation in prospective studies.