Lactobacillus reuteri SKLAN202402ZF inhibited by early-life lincomycin exposure alleviate intestinal damage and inflammation sensitivity - PubMed
4 days ago
- #Antibiotic-associated inflammation
- #Lactobacillus reuteri
- #Gut microbiota
- Early-life lincomycin exposure affects gut microbiota and intestinal health, with Lactobacillus reuteri being suppressed.
- Lincomycin exposure causes intestinal damage and reduces the expression of tight junction proteins (Claudin-1, Occludin, ZO-1).
- Mice with lincomycin-exposed fecal microbiota showed increased inflammation and weight loss after LPS infection.
- Supplementation with Lactobacillus reuteri SKLAN202402ZF reduced intestinal damage and inflammation post-LPS infection.
- Lactobacillus reuteri SKLAN202402ZF inhibits TLR4, MyD88, and NLRP3 expression, reducing inflammatory cytokines (IL-1β, IL-18, IL-17).
- Lincomycin increases susceptibility to LPS-induced inflammation, while Lactobacillus reuteri SKLAN202402ZF offers protective effects.