OTUD1 Relieves Coxsackievirus-Induced Ferroptosis and Inflammation in Myocardial Cells by Stabilizing NRF2 and Inhibiting NF-κB Signaling - PubMed
5 hours ago
- #NF-κB signaling
- #viral myocarditis
- #ferroptosis
- OTUD1 alleviates Coxsackievirus B3 (CVB3)-induced inflammation and ferroptosis in myocardial cells.
- CVB3 infection reduces OTUD1 expression and increases inflammatory cytokines (IL-1β, IL-6, TNF-α) and ferroptosis markers (Fe2+, MDA, ROS).
- OTUD1 overexpression stabilizes NRF2 and inhibits NF-κB signaling, mitigating CVB3-induced myocardial damage.
- Study suggests OTUD1 as a potential therapeutic target for viral myocarditis (VMC).